Nucleotide sequence of Clostridium difficile toxin A
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چکیده
منابع مشابه
Nucleotide sequence of Clostridium difficile toxin B gene
Clostridium difficile, the causative agent of antibiotic-associated pseudomembranous colitis, produces two toxins, A and B (1). Toxin A is both an enterotoxin and cytotoxin, whereas toxin B is a highly potent cytotoxin (2,3,4). Toxin A has been cloned and sequenced by our research team (5) and later by Sauerborn and von Eichel-Streiber (6). The entire coding region of toxin B and 398 bp of the ...
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Binary toxin (CDT) is frequently observed in Clostridium difficile strains associated with increased severity of C. difficile infection (CDI). CDT belongs to the family of binary ADP-ribosylating toxins consisting of two separate toxin components: CDTa, the enzymatic ADP-ribosyltransferase which modifies actin, and CDTb which binds to host cells and translocates CDTa into the cytosol. CDTb is a...
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JOHN STEPHEN,* SUSAN C. REDMOND,* TIMOTHY J. MITCHELL,* JULIAN KETLEY,* DAVID C. A. CANDY,? DOUGLAS W. BURDONt and RICHARD DANIEL§ *Department of Microbiology. University of Birmingham, P.O. Box 363, Birmingham B15 ZTT, U.K., tlnstitute of Child Health, Francis Road, Edgbaston, Birmingham B16 8ET. U.K. , $Department of Microbiology, General Hospital, Steelhouse Lane, Birmingham B4 6NH U.K. , an...
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It is known that the major etiologic agent of pseudomembranous colitis in man is Clostridium difficile. With respect to traditional use of almond paste in the treatment of infantile diarrhea, we studied the effects of the aqueous extract of Amygdalus communis (AEAC) on the growth and toxin production of Clostridium difficile in culture medium and the rabbit ligated ileal loop. Three groups...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1990
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/18.6.1629